Innovative and culturally tailored interventions
The ARISE-DP program develops innovative population-level interventions including designing and testing culturally tailored point-of-care diagnostics, as well as developing treatment/preventive methods to improve sleep quality, reduce the occurrence of Obstructive Sleep Apnea, hypertension, inflammation and stress - all of which are novel therapeutic targets for Alzheimer's Disease (AD).
A quick look into our studies
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01
Using a health disparity research framework to examine mechanisms linking Obstructive Sleep Apnea (OSA) with higher Alzheimer's disease risk in older Black/African Americans (ASCEND)
This study generates preliminary data for a larger R01 application by examining whether black patients with OSA exhibit more severe Alzheimer’s disease pathology (i.e., higher tau and greater neurodegeneration), and have worse deep sleep measure (i.e., decreased non-rapid eye movement (NREM) slow wave activity (SWA)) and increased inflammation compared to whites. The proposal will also examine whether socioeconomic and vascular risk measures drive any observed race-specific effects of the OSA-AD relationship.
Using a health disparity research framework to examine mechanisms linking Obstructive Sleep Apnea (OSA) with higher Alzheimer's disease risk in older Black/African Americans (ASCEND)
This study generates preliminary data for a larger R01 application by examining whether black patients with OSA exhibit more severe Alzheimer’s disease pathology (i.e., higher tau and greater neurodegeneration), and have worse deep sleep measure (i.e., decreased non-rapid eye movement (NREM) slow wave activity (SWA)) and increased inflammation compared to whites. The proposal will also examine whether socioeconomic and vascular risk measures drive any observed race-specific effects of the OSA-AD relationship.
Assessing the treatment of obstructive sleep apnea on sleep dependent memory and blood biomarkers in black study participants (BLOSOM)
This study generates preliminary data for a larger R01 application by examining whether black patients with OSA exhibit more severe Alzheimer’s disease pathology (i.e., higher tau and greater neurodegeneration), and have worse deep sleep measure (i.e., decreased non-rapid eye movement (NREM) slow wave activity (SWA)) and increased inflammation compared to whites. The proposal will also examine whether socioeconomic and vascular risk measures drive any observed race-specific effects of the OSA-AD relationship.
Assessing the treatment of obstructive sleep apnea on sleep dependent memory and blood biomarkers in black study participants (BLOSOM)
This study generates preliminary data for a larger R01 application by examining whether black patients with OSA exhibit more severe Alzheimer’s disease pathology (i.e., higher tau and greater neurodegeneration), and have worse deep sleep measure (i.e., decreased non-rapid eye movement (NREM) slow wave activity (SWA)) and increased inflammation compared to whites. The proposal will also examine whether socioeconomic and vascular risk measures drive any observed race-specific effects of the OSA-AD relationship.
02
03
The mediating role of Slow Wave Sleep (SWS) and Vascular Risk Factors (VRFs) on Alzheimer’s Disease related disparity between African-Americans and non-Hispanic Whites (PRIMARY)
This study generates preliminary data for a larger R01 application by examining whether black patients with OSA exhibit more severe Alzheimer’s disease pathology (i.e., higher tau and greater neurodegeneration), and have worse deep sleep measure (i.e., decreased non-rapid eye movement (NREM) slow wave activity (SWA)) and increased inflammation compared to whites. The proposal will also examine whether socioeconomic and vascular risk measures drive any observed race-specific effects of the OSA-AD relationship.
The mediating role of Slow Wave Sleep (SWS) and Vascular Risk Factors (VRFs) on Alzheimer’s Disease related disparity between African-Americans and non-Hispanic Whites (PRIMARY)
This study generates preliminary data for a larger R01 application by examining whether black patients with OSA exhibit more severe Alzheimer’s disease pathology (i.e., higher tau and greater neurodegeneration), and have worse deep sleep measure (i.e., decreased non-rapid eye movement (NREM) slow wave activity (SWA)) and increased inflammation compared to whites. The proposal will also examine whether socioeconomic and vascular risk measures drive any observed race-specific effects of the OSA-AD relationship.
Mechanisms of racial differences in the relationship between Obstructive Sleep Apnea and in vivo Tau deposition in the context of Amyloid burden (MAINSTAY)
This study generates preliminary data for a larger R01 application by examining whether black patients with OSA exhibit more severe Alzheimer’s disease pathology (i.e., higher tau and greater neurodegeneration), and have worse deep sleep measure (i.e., decreased non-rapid eye movement (NREM) slow wave activity (SWA)) and increased inflammation compared to whites. The proposal will also examine whether socioeconomic and vascular risk measures drive any observed race-specific effects of the OSA-AD relationship.
Mechanisms of racial differences in the relationship between Obstructive Sleep Apnea and in vivo Tau deposition in the context of Amyloid burden (MAINSTAY)
This study generates preliminary data for a larger R01 application by examining whether black patients with OSA exhibit more severe Alzheimer’s disease pathology (i.e., higher tau and greater neurodegeneration), and have worse deep sleep measure (i.e., decreased non-rapid eye movement (NREM) slow wave activity (SWA)) and increased inflammation compared to whites. The proposal will also examine whether socioeconomic and vascular risk measures drive any observed race-specific effects of the OSA-AD relationship.
04
-Inactive -
05
Racial differences in the association of slow wave sleep and Tau (RESOLVENT)
This pilot study leverages existing ADRC infrastructure and ongoing NIH funded R01 studies by adding tau-PET imaging. The proposal examines whether non-Hispanic black participants with worse deep sleep measures (i.e., decreased non-rapid eye movement (NREM)slow wave sleep and activity (SWA/SWS) will exhibit worse Alzheimer’s Disease pathology (i.e., higher brain tau and amyloid PET levels), and whether non-Hispanic black participants with normal SWS/SWA will exhibit similar or even lower tau-PET brain signal than their white counterparts for similar levels of amyloid burden.
Racial differences in the association of slow wave sleep and Tau (RESOLVENT)
This pilot study leverages existing ADRC infrastructure and ongoing NIH funded R01 studies by adding tau-PET imaging. The proposal examines whether non-Hispanic black participants with worse deep sleep measures (i.e., decreased non-rapid eye movement (NREM)slow wave sleep and activity (SWA/SWS) will exhibit worse Alzheimer’s Disease pathology (i.e., higher brain tau and amyloid PET levels), and whether non-Hispanic black participants with normal SWS/SWA will exhibit similar or even lower tau-PET brain signal than their white counterparts for similar levels of amyloid burden.
Race-specific regional Tau deposition and role of Obstructive Sleep Apnea (RETOSA)
This pilot study leverages existing ADRC infrastructure and ongoing NIH funded R01 studies by adding tau-PET imaging. The proposal plans to elucidate OSA-dependent race-specific differences in regional brain tau deposition in the context of Aβ burden and how this impacts the rate of clinical progression in early AD.
Race-specific regional Tau deposition and role of Obstructive Sleep Apnea (RETOSA)
This pilot study leverages existing ADRC infrastructure and ongoing NIH funded R01 studies by adding tau-PET imaging. The proposal plans to elucidate OSA-dependent race-specific differences in regional brain tau deposition in the context of Aβ burden and how this impacts the rate of clinical progression in early AD.
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